Hydrolyzed DNA Low Molecular Weight (LMW) PDRN is essentially short-chain DNA fragments derived from DNA hydrolysis, positioned between classic PDRN and nucleotides.
Plainly and precisely:
What it is
* DNA broken down into low–molecular weight oligo- and polynucleotides
* Often derived from salmon or plant sources
* Smaller than traditional PDRN, larger than single nucleotides
* Water-soluble, cosmetic- and dermal-use friendly
Why LMW matters
* Smaller fragments = better skin penetration
* Faster interaction with skin cells compared to high-MW DNA
* More compatible with topical and semi-liposomal systems
Biological role (mechanism)
* Acts as a nucleotide donor pool for damaged or stressed cells
* Supports cellular repair, regeneration, and barrier recovery
* Indirectly supports fibroblast activity and ECM recovery
* Milder signaling than growth factors, safer for frequent use
How it differs
* vs PDRN (classic):
* PDRN is larger, slower, often injection-focused
* LMW Hydrolyzed DNA is topical-first, faster, gentler
* vs Sodium DNA / NaDNA:
* NaDNA usually higher MW and salt-form
* Hydrolyzed DNA is more flexible in formulation
Typical cosmetic use levels
* 0.05–0.5% common
* Premium / post-procedure formulas may go higher depending on MW and purity
* Often paired with niacinamide, panthenol, ectoin, peptides, or copper systems
Formulation notes
* Stable in pH ~5.0–6.5
* Compatible with HA systems and lipid-assisted carriers
* Avoid strong acids, harsh oxidizers, aggressive chelators
* Works well in recovery, post-needle, barrier-repair SKUs
Positioning logic
* Think of it as “cellular repair nutrition”, not a growth-factor replacement
* High trust, low drama, repeat-use safe
* Excellent for recovery lines, premium boosters, clinic-adjacent products
In short: LMW Hydrolyzed DNA is the most commercially practical, penetration-optimized evolution of PDRN for topical use.
Not hype. Just good molecular ergonomics.
SKU: PDP
